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Mesothelioma Clinical Trials & Emerging Treatments
Aside from conventional treatments, many mesothelioma patients turn to clinical trials to potentially extend survival. These experimental studies are small and controlled opportunities for scientists to test new drugs, therapies and different combinations of treatments. Participating in such trials can advance medical knowledge and help other patients with this disease both now and in the future.
Clinical trials often become an option for patients whose traditional treatments were unsuccessful or for those not eligible for surgery.
Mesothelioma survivor Walter Merth
“The therapy has given me a new window. It’s like getting my life back.”
– Mesothelioma survivor Walter Merth on participating in Keytruda clinical trial
Immunotherapy
Immunotherapy is a promising cancer treatment only available to mesothelioma patients through clinical trials. Checkpoint inhibitors, such as pembrolizumab (Keytruda) and avelumab (Bavencio), have shown encouraging results in multicenter trials testing the drugs in combination with surgery and chemotherapy regimens. In May 2017, the U.S. Food and Drug Administration approved pembrolizumab as a first-line treatment of metastatic non-small cell lung cancer, making approval for mesothelioma a possibility in the near future.
53
mesothelioma clinical trials active or recruiting patients worldwide since 2016
Photodynamic Therapy
Photodynamic therapy uses light to better target cancer cells with chemotherapy. A 2016 clinical trial at the Penn Medicine Abramson Cancer Center nearly doubled survival for pleural mesothelioma patients who received intraoperative photodynamic therapy (PDT) and chemotherapy following a P/D procedure.
Cryotherapy
The process of killing tumor cells by exposing them to extreme cold — known as cryotherapy — is a viable treatment option for mesothelioma patients in the few places that offer the procedure. Unlike many treatments, cryotherapy causes few side effects. In May 2015, the Mayo Clinic in Rochester, Minnesota, opened the only ongoing cryotherapy clinical trial for mesothelioma in the U.S.
Aside from conventional treatments, many mesothelioma patients turn to clinical trials to potentially extend survival. These experimental studies are small and controlled opportunities for scientists to test new drugs, therapies and different combinations of treatments. Participating in such trials can advance medical knowledge and help other patients with this disease both now and in the future.
Clinical trials often become an option for patients whose traditional treatments were unsuccessful or for those not eligible for surgery.
Mesothelioma survivor Walter Merth
“The therapy has given me a new window. It’s like getting my life back.”
– Mesothelioma survivor Walter Merth on participating in Keytruda clinical trial
Immunotherapy
Immunotherapy is a promising cancer treatment only available to mesothelioma patients through clinical trials. Checkpoint inhibitors, such as pembrolizumab (Keytruda) and avelumab (Bavencio), have shown encouraging results in multicenter trials testing the drugs in combination with surgery and chemotherapy regimens. In May 2017, the U.S. Food and Drug Administration approved pembrolizumab as a first-line treatment of metastatic non-small cell lung cancer, making approval for mesothelioma a possibility in the near future.
53
mesothelioma clinical trials active or recruiting patients worldwide since 2016
Photodynamic Therapy
Photodynamic therapy uses light to better target cancer cells with chemotherapy. A 2016 clinical trial at the Penn Medicine Abramson Cancer Center nearly doubled survival for pleural mesothelioma patients who received intraoperative photodynamic therapy (PDT) and chemotherapy following a P/D procedure.
Cryotherapy
The process of killing tumor cells by exposing them to extreme cold — known as cryotherapy — is a viable treatment option for mesothelioma patients in the few places that offer the procedure. Unlike many treatments, cryotherapy causes few side effects. In May 2015, the Mayo Clinic in Rochester, Minnesota, opened the only ongoing cryotherapy clinical trial for mesothelioma in the U.S.